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KMID : 1035120200200020083
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Asian Oncology Nursing
2020 Volume.20 No. 2 p.83 ~ p.91
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Chemotherapy-induced Peripheral Neuropathy in Patients with Breast Cancer: Associated Factors and Impact on Health-Related Quality of Life
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Choe Yu-Hyeon
Kim Soo-Hyun
Oh Hyun-Soo
Seo Wha-Sook·
Lee Sun-Hee
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Abstract
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Purpose: This study aimed to identify factors associated with the occurrence of chemotherapy-induced peripheral neuropathy(CIPN) and to study its impact on health-related quality of life (HRQoL) in patients with breast cancer.
Methods: In total, 137 women with breast cancer who had undergone more than one cycle of chemotherapy were recruited for this descriptive study from the outpatient department of a university hospital in Incheon, Korea. Data were collected using a self-reported questionnaire, which included the European Organization for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 and EORTC QLQ-C30.
Results: The mean CIPN score between patients was 13.57 on the sensory scale, 15.87 on the motor scale, and 25.06 on the autonomic scale. Of the studied socio-demographic, disease and treatment, and health behavior-related factors, only the chemotherapy regimen was significantly associated with CIPN (t = 2.50, p= .013). Taxane-based chemotherapy was significantly related to higher CIPN scores. Regression analyses revealed that CIPN was a factor that was significantly influential on HRQoL, adjusting for socio-demographic and clinical factors.
onclusion: This study suggests that oncology nurses need to be aware of the increased risk of CIPN in patients with breast cancer undergoing taxane-based chemotherapy. In addition, interventions for alleviating CIPN may be required to improve HRQoL among these patients.
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KEYWORD
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Breast neoplasms, Chemotherapy, Peripheral neuropathy, Health-related quality of life
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